Topic: miniscopes

Primary sensory cortical areas are characterized by low-level representations of sensory inputs, but whether these representations are stable over a long period of time or whether they are continuously renewed is still unclear. The head-direction (HD) signal is essential for the spatial navigation system. In the cortex, it is processed by the postsubiculum (PoSub). HD cells each fire for a specific direction of the head of the animal in the horizontal plane and constitute a vast majority of PoSub principal neurons. To address the question of representational stability, we used one-photon calci

Primary sensory cortical areas are characterized by low-level representations of sensory inputs, but whether these representations are stable over time or are continuously renewed is unclear. The head-direction (HD) signal is essential for the spatial navigation system, where it has previously been found that place representation is unstable over long periods of time. In the cortex, the HD signal is processed by the postsubiculum (PoSub). HD cells constitute a vast majority of PoSub principal neurons. Each HD cell fires towards a specific direction of the head of the animal in the horizontal p

Post-traumatic stress disorder (PTSD) emerges in the aftermath of a traumatic event, underscoring the pressing need for research into preventive treatments. Adrenal glucocorticoids induce short-term physiological adaptations necessary to cope with the threat. Evidence indicates that when administrated after trauma, glucocorticoids prevent the development of PTSD. The basolateral amygdala (BLA) is a key structure for processing positive and negative valence which communicates bidirectionally with other regions to regulate the stress responses. The present study evaluates the efficacy of cortico

Motivated behaviors such as feeding, drinking, and social behaviors, and the ability to efficiently switch between them, are essential for survival. The lateral hypothalamus (LH) plays a central role in orchestrating motivated behaviors. As there is minimal local synaptic communication within the LH, long-range synaptic input is critical to LH neural computations. In particular, the medial prefrontal cortex (mPFC), which integrates complex information about the environment, projects to the LH. However, it is unknown when mPFC to LH projection neurons are active. In this study, we combine in vi