Topic: misfolded proteins

Aging leads to the accumulation of misfolded proteins, such as β-amyloid and α-synuclein, which are believed to underly the onset of neurodegenerative disorders. Most of the treatments for brain disorders come from pre-clinical evidence in males, although women are more vulnerable than men to Alzheimer’ disease (AD) which is the first cause of age-related dementia. However, the mechanisms underlying these sex-differences are not known.To date, two therapeutic approaches are predominantly used to prevent and/or slow neurodegeneration; they include autophagy pharmacological enhancers and exercis