Topic: Mitochondrial dynamics

Farhad Danesh examines how mitochondrial reactive oxygen species, altered metabolism and structural remodelling convert hyperglycaemia into progressive kidney injury. The seminar connects mitochondrial dynamics with diabetic microvascular damage, non-coding RNA regulation and experimental models that establish causal links to disease progression. Genome-wide CRISPR screens and spatial metabolomics reveal cellular gene-regulatory and metabolic changes. Integrating these approaches with molecular genetics, genomics and epigenomics, the work seeks therapeutic targets to prevent diabetic kidney di