Topic: neuronal transcriptome

Aims: Metabolic profile impacts on tissue development including neurons in brain, yet the full repertoire of metabolic signals that shape developing neuronal architecture remain mysterious. Our aim is to clarify the metabolic crosstalk that coordinates the early acquisition of the neurite complexity in developing neurons. Methods: To investigate the factors involved in metabolic switch, we used transcriptomics analysis on the sensory neurons cultured in different metabolic demand. IPA analysis was used to interpret the transcriptomics data. We applied MEME-ChIP method on comprehensive motif an

Due to the complexity of CNS, studying the aging processes at the level of neural circuits and individually identified neurons is not an easy task in vertebrates, hence aging research heavily relies on invertebrate models. One such model is the great pond snail (Lymnaea stagnalis), which has been used extensively to study cognitive aging.We made the neuronal transcriptome assembly of Lymnaea and identified several evolutionarily conserved homolog sequences to genes involved in aging, age-related memory impairment, and neurodegenerative diseases of vertebrates including humans. Using young (3-4