Topic: population studies

Studies of families with inherited breast-cancer risk led to BRCA1 and subsequently many other susceptibility genes. This seminar examines how large-scale sequencing and population studies have refined tumour associations and penetrance estimates. It moves from a simple dominant-inheritance model toward multifactorial risk, considering genetic and environmental modifiers that could support individualized surveillance and management.

This presentation will include a brief resume of research in older populations led from Cambridge that have informed current clinical understanding and policy regarding services and prevention for and of dementia. These population studies have more recently been ‘re-purposed’ with enthusiasm from participants into a trial platform, and this also has enabled ongoing follow-up by telephone during the COVID pandemic. Although there are no formal outputs from these latter developments general impressions will be shared.