Protein aggregation

…and develop quantitative measures of protein aggregation, inflammation, cell loss and vascular integrity. Collaborate with pharmacology, histology, molecular biology and computational teams to turn mechanistic findings into programme decisions. The employer’s current vacancy accepts applications without a stated fixed deadline.

Alzheimer's disease (AD) is a progressive degenerative disorder characterized by memory loss and cognitive decline. However, there are limited studies on preventing or stopping the advanced neuronal loss that occurs during or before the disease. Our project aims to provide a prophylactic application against AD and similar neurodegenerative diseases. Exosomes are small particles that can cross biological membranes like the blood-brain barrier. They are being used as drug carrier systems and have attracted attention recently. In AD and similar diseases, exposure to oxidant molecules increases in

Pathological protein aggregation and synaptic dysfunction are major contributors to neurodegenerative disorders. However, understanding disease-relevant protein aggregation, such as Beta-amyloid, Alpha-synuclein and Tau aggregation within synapses, remains limited. To address this, we present a novel method for visualizing protein aggregates in individual synaptosomes. We combined Single-molecule Pull Down (SiMPull) and direct Stochastic Optical Reconstruction Microscopy (dSTORM), to immobilize individual synaptosomes and characterize single aggregates within them with ~20nm spatial resolution

…a polyglutamine tract in their encoded proteins, leading to their aggregation. Patients suffering from these disorders display movement impairments, and no effective treatment exists, leading to death 10-15 years after disease onset. Until now, nearly all attempts to use traditional N-methyl-d-aspartate receptor (NMDAR) antagonists to treat neurodegenerative diseases have failed. This is because NMDARs are not only promoters

…ubiquinated and phosphorylated proteins. Recent evidence also suggests that protein misfolding can propagate throughout the body in a prion-like fashion via the interstitial or cerebrospinal fluids (CSF). As protein aggregation occurs well before the onset of brain damage and symptoms, new biomarkers sensitive to early pathology, together with therapeutic strategies that include eliminating seed proteins and blocking cell-to-cell spread, are of vital importance.