Protein design

Natural proteins solve problems shaped by evolution. David Baker describes a different approach: designing proteins from scratch to meet current challenges in health, technology and sustainability. His laboratory develops deep-learning methods that generate proteins with new functions, synthesizes genes encoding the designs, and experimentally characterizes the resulting molecules. The lecture explains how this design-build-test approach extends beyond modifying existing natural proteins and presents applications of computational protein design to contemporary problems. Online via the Royal S

Machine learning has enabled advances in protein design and genetic circuits, but biological engineering still faces problems of interpretability, uncertainty and connections between molecular and system-level behaviour. Applied mathematicians, learning researchers and synthetic biologists will explore statistical methods for complex biological data, models that expose mechanisms, stochastic descriptions of noisy systems, multiscale modelling from molecules to populations and robust optimization for design under uncertainty. The workshop aims to develop mathematical foundations for more depend

…lipid chemistry, formulation, protein design and bioconjugation with cell-based assays and animal studies. Responsibilities include translating delivery research across species, directing a research team and shaping scientific publications and intellectual property. This full-time laboratory leadership position is fully onsite in South Boston, Massachusetts.

This EMBO workshop covers emerging chemical-biology research spanning computational protein design, big data and AI, technologies for probing and manipulating biology, chemical synthetic biology, and RNA.

…dynamics simulation algorithm, protein design and structural refinement tools. Using these methodologies, we describe therapeutic strategies to combat this HIV and cancer, as well as design novel approaches for controlling proteins in living cells and organisms.