Redox homeostasis

…Recently, an imbalance in redox homeostasis and exacerbated inflammatory response have been shown to play a central role in the diverse clinical manifestations of the disease.Numerous studies have highlighted that p75 neurotrophin receptor (p75NTR) may have a role in the regulation of oxidative stress (OS) and inflammation.Therefore, the aim of this work was to evaluate whether the modulation of p75NTR by LM11A-31 counteracts the alterations in OS and

Metabolic Syndrome (MetS) and obesity correlate with cognitive impairment, heightening the susceptibility to cognitive decline and dementia. Noteworthy, cognitive impairment exacerbates weight management challenges in MetS, giving rise to a "cognitive decline-MetS" loop. Indeed, various cognitive and affective functions, including memory and executive functions, were found to be compromised in MetS, with underlying mechanistic pathways supporting a potential role of oxy-inflammatory signaling.Our research delves into the nuanced realm of cognitive alterations in MetS by examining the correlati

…mitochondrial dysfunction, aberrant redox homeostasis, and subclinical inflammation, significantly contribute to RTT. The unique pathogenic development of RTT involves a relatively slow transition to the symptomatic stage, providing a critical time window for early diagnosis