Resilience

…invasions, climate extremes, resilience and sustainability. Proposed themes connect food, energy and water systems, urban and human-influenced environments, and the distinctive value of long-term observations. The programme includes scientific sessions, working groups and training activities, linking sustained monitoring with ecological understanding and environmental responses.

…as a period of both vulnerability and resilience. Drawing on more than a decade observing chimpanzees, the presentation brings together biological, anthropological, psychological and neuroscientific perspectives through cross-species empirical research. It connects questions about development in our closest living relatives with understanding the human life course; Reddy’s fellowship work also includes a coming-of-age novel informed by the lives of the chimpanzees she studies.

…with the mechanisms of resilience

Older people remain underrepresented in translational studies, primarily due to the challenges associated with including aged animals. Their low survivorship, frailty status and heterogeneity hinder their use in longitudinal studies. Furthermore, social isolation, a prevalent issue among this population, is difficult to replicate in animals of advanced age. This study aims to evaluate the impact of social isolation on a cohort of surviving, aged animals in three different behavioral dimensions. A total of 37 C57BL/6J mice of both sexes were assessed in a longitudinal design over a three-month

…either towards or away from resilience. Stress is a powerful trigger of regulation methods and past research reveals substantive correlations between stress and rumination, which is a response type involving repetitive thoughts about the stress-inducing stimulus and its causes or consequences. Importantly, both are implied in the pathogenesis of several somatic and psychiatric health conditions.The causal direction between stress and rumination remains unclear, pa

Early-life adversity (ELA) is a leading risk factor for developing mental disorders such as depression or anxiety in adulthood. Some of its anatomical and molecular correlates were described under multiple stress paradigms, acute and chronic alike, in various species. However it is unclear how the cellular substrate of traumatic memories associated with ELA evolves through life and can participate in its behavioral outcome. To allow lifelong tracking of neuronal populations recruited during early-life stress we used FosTRAP2 mice in a juvenile (P21) social defeat model (jSD), in which neuronal

…Although the connection between resilience and cognitive performance in older adults has been explored, the neural mechanisms underlying this relationship remain elusive. Processing speed is vital for daily functioning and independence among older adults Specifically, how resilience impacts intrinsic FC within brain networks and individuals' processing speed has yet to be thoroughly addressed. To uncover this question, we recruited 102 healthy ageing individuals aged 60-79 to complete a rest

Resilience, defined as the ability to positively adapt to stress, is intricately linked to various neurobiological systems, with the noradrenergic (NE) system being a key player. As a primary modulator of the stress response, the NE system also holds significance in brain development, particularly during critical periods. Recent findings in both mice and humans have underscored its role in promoting resilience in the aftermath of stressful events during adulthood. Nonetheless, limited evidence exists regarding its involvement in resilience following child abuse.`To address this inquiry, we emp

Humans and other animals evolved in habitats fraught with a range of environmental challenges to their bodies and brains. Accordingly, cells and organ systems possess adaptive stress-responsive signaling pathways that enable them to not only withstand environmental challenges, but also to prepare for future challenges and function more efficiently. These phylogenetically conserved processes are the foundation of the hormesis principle in which repeated exposures to low to moderate amounts of an environmental challenge improve cellular and organismal fitness. Here I describe cellular and molecu

…mood disorders in the promotion of resilience against neurodegenerative disorder. In his presentation Dr. Pasinetti will discuss novel concepts about the gut-brain axis in mechanisms associated to peripheral adaptive immunity as therapeutic targets to mitigate the onset and the progression of Alzheimer’s disease and other form of dementia.

In the United States, racial/ethnic inequalities in Alzheimer's disease and related dementias persist even after controlling for socioeconomic factors and physical health. These persistent and unexplained disparities suggest: (1) there are unrecognized dementia risk factors that are socially patterned and/or (2) known dementia risk factors exhibit differential impact across social groups. Pursuing these research directions with data from multiple longitudinal studies of brain and cognitive aging has revealed several challenges to the study of late-life health inequalities, highlighted evidence

There are stories of resilience, passion, braveness and determination and the one of Onur Güntürkün. He has managed to beat the odds in so many ways, from moving countries, surviving the polio, establishing a new field against the advice of a senior professor and much more, all the while keeping a positive spirit, an endless curiosity and the braveness to keep going despite adversities. Join me on Monday, February 28, 2022, 6 p.m. (CET) for a Growing Up in Academia with Onur Güntürkün.

Black Americans experience diverse racism-related stressors throughout the lifespan. Disproportionately high trauma exposure, economic disadvantage, explicit racism and inequitable treatment are stressors faced by many Black Americans. These experiences have a cumulative negative impact on psychological and physical health. However, little is understood about how experiences of racism, such as discrimination, can mediate health outcomes via their effects on neurobiology. I will present clinical, behavioral, physiological and neurobiological data from Black American participants in the Grady Tr

…change in behavioural traits of resilience to addiction, exacerbate the vulnerability to develop compulsive drug intake. I will further discuss the importance of the acquisition of alcohol drinking as a mechanism to cope with distress as a factor of

…underlying structure on differential resilience of individuals to a variety of environmental perturbations, including changes in temperature, pH, potassium concentration and neuromodulation. We show that neurons with many different kinds of ion channels can smoothly move through different mechanisms

…underlying structure on differential resilience of individuals to a variety of environmental perturbations, including changes in temperature, pH, potassium concentration and neuromodulation. We show that neurons with many different kinds of ion channels can smoothly move through different mechanisms