Seminar · Molecular Neuroscience
Understanding the cellular and molecular landscape of autism spectrum disorders
Karun Singh · Krembil Research Institute, University Health Network, Toronto, Faculty of Medicine, University of Toronto
Mon, Mar 15, 2021 · 06:00 UTC
Large genomic studies of individuals with autism spectrum disorders (ASD) have revealed approximately 100-200 high risk genes. However, whether these genes function in similar or different signaling networks in brain cells (neurons) remains poorly studied. We are using proteomic technology to build an ASD-associated signaling network map as a resource for the Autism research community. This resource can be used to study Autism risk genes and understand how pathways are convergent, and how patient mutations change the interaction profile. In this presentation, we will present how we developed