Topic: single-cell analysis

Develop interpretable computational tools for molecular and spatial analysis of tumour-cell plasticity in pancreatic ductal adenocarcinoma. Within the AIMPACT collaboration, the BioTiC team seeks an engineer to turn prototype differential-network software into a documented Python package, add visualization and example notebooks, and identify regulatory processes for biological follow-up. Relevant skills include software engineering, statistics, machine learning, single-cell analysis, network inference or Python/R; an interest in cancer biology and strong English are valuable. Appointment: 2 ye

Genomics, proteomics and imaging now measure molecules and cells across many scales. This workshop examines how mechanistic models can integrate those measurements and biological dynamics to explain and engineer cellular behaviour. Researchers in single-cell analysis, dynamic proteomics, quantitative imaging, synthetic biology and theory will connect experimental and computational approaches. The programme links three themes: cell dynamics and interactions; molecular mechanisms and engineering; and rigorous quantitative models. Sessions address multiscale modelling, molecules over time, large-

Investigate the mechanisms of cellular rejuvenation and resilience through multidisciplinary experimental research. Develop project-specific methods, contribute to collaborations and publications, and help train researchers and graduate students. Relevant areas include epigenetics, metabolism, stem cells, single-cell analysis, functional screening and gene delivery. Multiple scientist levels are available, with advertised salary bands spanning USD 116,450–247,000 depending on level.

Yun Xia presents macrophage–kidney assembloids that address missing immune and vascular components in stem-cell organoids. Directed differentiation, self-organization, genetic perturbation, xenotransplantation and single-cell analysis reveal immune–epithelial interactions. Macrophages from the same parental cells acquire resident phenotypes; diabetic and polycystic kidney models show context-dependent effects on inflammation, epithelial injury and disease progression. Minoru Takasato addresses kidney organoids’ missing urinary outflow by generating bladder tissue from human pluripotent cells.

The advent of next generation sequencing ushered in a ten-year period of exuberant technology development, enabling the quantification of gene expression and epigenetic features within individual cells, and within intact tissue sections. In this seminar, I will outline our technological contributions, beginning with the development of Drop-seq, a method for high-throughput single cell analysis, followed by the development of Slide-seq, a technique for measuring genome-wide expression at 10 micron spatial resolution. Using a combination of these techniques, we recently constructed a compreh

The thalamic reticular nucleus (TRN), the major source of thalamic inhibition, is known to regulate thalamocortical interactions critical for sensory processing, attention and cognition. TRN dysfunction has been linked to sensory abnormality, attention deficit and sleep disturbance across multiple neurodevelopmental disorders. Currently, little is known about the organizational principles underlying its divergent functions. In this talk, I will start with an example of how dysfunction of TRN contributes to attention deficit and sleep disruption using a mouse model of Ptchd1 mutation, which in

The medial prefrontal cortex (mPFC) plays a crucial role in integrating sensory input for learned stimulus-response associations. However, the link between sensory stimuli and changing behavioral relevance remains poorly understood. We studied how sensory stimuli and neural representations of associated behaviors emerge in mPFC during avoidance learning.We performed mobile population calcium imaging in mice mPFC during an active avoidance task. In this task, mice learned to avoid an aversive foot shock associated with conditioned tone stimuli CS1 and CS2. CS1 was first followed by the shock in