Single-cell genomics

A Keystone Symposium bringing together single-cell genomics, spatial biology, perturbation technologies, computational methods, and clinical translation across high-burden diseases.

…and disease mechanisms, using single-cell genomics and advanced microscopy alongside molecular approaches. The programme also considers how ageing, environmental exposures and lifestyle influence epigenetic states. The meeting brings together researchers working across

The Research Luke Harland is establishing a new research group based in the Loke Centre for Trophoblast Research within the Department of Physiology, Development and Neuroscience at the University of Cambridge. The group investigates how specialised blood and vascular cell types arise during mammalian development and uses this knowledge to generate defined cell populations from pluripotent stem cells for mechanistic studies and tissue modelling. We aim to understand how developmental history shapes blood and vascular cell identity and function, and to apply this knowledge to build improved vas

…bacterial experiments with modern single-cell genomics. The lecture asks how mutations accumulate during human life, how they contribute to cancer and how tumour evolution can be reconstructed. It illustrates how measurements of individual cells help address these questions.

The entry of peripheral immune cells into brain border areas like the choroid plexus and meningesis established, but the mechanism regulating their infiltration and functional role is not fullyunderstood. Our study sheds light on the role of serotonin in the migration of these cells and theirinvolvement in the action of selective serotonin reuptake inhibitors (SSRIs). We found thatfluoxetine (FLX), which is known to boost available serotonin, led to a higher number of immunecells found in the brain (parenchyma and borders) of socially isolated mice. By employing spatial transcriptomics and sin