Topic: single-cell RNA-seq

Spiny projection neurons (SPNs) in the mouse striatum transform multimodal inputs from the cortex and thalamus into inhibitory outputs that regulate basal ganglia activity. SPNs are typically classified into major populations according to their output projection targets and their location within striatal anatomical and neurochemical domains. However, how the cellular and circuit diversity within these broad populations is established developmentally remains largely unknown. We have previously shown that SPNs derived from a distinct apical intermediate progenitor (aIP) pool are preferentially d