Topic: SNARE complex

Tetanus Neurotoxin (TeNT) enters the peripheral endings of motor axons in muscles and transports to motoneuron cell bodies where transynaptically translocates to presynaptic inputs blocking inhibitory synapses. This disinhibits motoneurons causing dysregulated firing and tetanic contractions. Preferential actions on inhibitory synapses are usually explained by enrichment in the Vesicle-Associated Membrane Protein 2 isoform (VAMP2). VAMP1 and VAMP2 form part of the SNARE complex and are differentially distributed in different synapses. Nevertheless, the exact VAMP content inside synapses on mot

AimStriatal cholinergic interneurons (CINs) use both acetylcholine (ACh) and glutamate (Glu) to regulate the striatal network. CINs express vesicular transporters for acetylcholine (VAChT) and Glu (VGLUT3). We recently demonstrated, using super resolution STimulated Emission Depletion microscopy (STED) microscopy, that part of cholinergic synaptic vesicles (SVs) contains both VAChT and VGLUT3, whereas others express only VAChT or only VGLUT3. CINs SVs are thus able to release either ACh or Glu or both. However, the link between neurotransmitters accumulation into SVs and their final exocytosis

Photoreceptors, the light sensors of the retina, come in two varieties: the light-sensitive rod photoreceptors, which are responsible for night vision, and the cone photoreceptors, which operate at higher light intensities and are responsible for daylight and color vision. These different tasks require specific morphological and molecular adaptations of rod and cone photoreceptors in the processes of transduction and transmission of light signals. Here we present the first deep proteome resource of mouse rod and cone photoreceptors to our knowledge. We have established a method using fluoresce