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Topic: VAMP2

ePoster
2 ePosters

In Neuroscience

Inhibitory synapses on spinal motoneurons express VAMP1 and VAMP2 and both are reduced by tetanus toxin while sparing these same VAMPs in adjacent excitatory synapses

Paula M Calvo, Ryan L Wood, Francisco J Alvarez · FENS Forum 2024

Tetanus Neurotoxin (TeNT) enters the peripheral endings of motor axons in muscles and transports to motoneuron cell bodies where transynaptically translocates to presynaptic inputs blocking inhibitory synapses. This disinhibits motoneurons causing dysregulated firing and tetanic contractions. Preferential actions on inhibitory synapses are usually explained by enrichment in the Vesicle-Associated Membrane Protein 2 isoform (VAMP2). VAMP1 and VAMP2 form part of the SNARE complex and are differentially distributed in different synapses. Nevertheless, the exact VAMP content inside synapses on mot

ePoster · Neuroscience

Nanoscopic distribution of VAMP2 and VAMP7 in striatal cholinergic varicosities and their respective localization with VAChT and VGLUT3 in synaptic vesicles

Mazarine Desplanque, Paola Cristofari, Odile Poirel, Alison Hébert, Sylvie Dumas, Véronique Fabre, Stéphanie Daumas, Nicolas Pietrancosta, Salah El Mestikawy, Véronique Bernard · FENS Forum 2024

AimStriatal cholinergic interneurons (CINs) use both acetylcholine (ACh) and glutamate (Glu) to regulate the striatal network. CINs express vesicular transporters for acetylcholine (VAChT) and Glu (VGLUT3). We recently demonstrated, using super resolution STimulated Emission Depletion microscopy (STED) microscopy, that part of cholinergic synaptic vesicles (SVs) contains both VAChT and VGLUT3, whereas others express only VAChT or only VGLUT3. CINs SVs are thus able to release either ACh or Glu or both. However, the link between neurotransmitters accumulation into SVs and their final exocytosis

ePoster · Neuroscience