Topic: stress resilience

In mice, social dominance has been associated with anxiety trait and reduced stress resilience. However, the underlying mechanisms of this association remain unknown. Here, we tested the hypothesis that adult hippocampal neurogenesis may underlie dominance behaviour and anxiety.First, our observations in group-housed males unveiled that dominant mice exhibited heightened trait anxiety and vulnerability to stress when compared to their subordinate counterparts. Furthermore, we observed a reduction in hippocampal neurogenesis specifically within the ventral hippocampus of stressed dominant mice.

Stress susceptibility is highly variable among individuals. For those with high stress susceptibility, they have a high risk of developing mental disorders such as depression upon exposure to social stress. Mice also show depression-like behavior following social stress, and the extent of behavioral changes are variable among individuals even under a uniform genetic background. The precise mechanisms that underlie variability in stress resilience among individuals are poorly understood. To elucidate the mechanisms, we focused on the long-term effects of repeated social defeat stress (SDS) in B

In the context of current global changes, a notable increase in major depressive and anxiety disorders worldwide has surfaced, underscoring the urgent need to comprehend stress resilience. The influence of stress on health is evident; however, not all individuals are predisposed to developing associated problems, as certain individuals demonstrate resilience. The animal models offer a valuable approach to investigating the mechanisms that differentiate resilience from vulnerability. Our research focuses on the endocannabinoid(eCB) system, specifically CB2 receptors, known for their roles in ne

Environmental enrichment (EE) is a husbandry procedure known to provide enhanced somatosensory, locomotor and cognitive stimulation. It has been shown to exert significant beneficial effects on cognitive function improving rodent behavior, altering neuronal plasticity, and promoting stress resilience. Concurrently, emerging research highlights the intricate bidirectional communication between the gut microbiome and central nervous system, known as the microbiota-gut-brain axis. Therefore, the aim of this work is to investigate, whether the beneficial effects of EE are linked to alterations in

Posttraumatic stress disorder (PTSD) severely deteriorates the quality of life of an increasing number of people. Fortunately, the majority of trauma-exposed individuals recovers successfully and shows resilience to these negative consequences of trauma. Understanding the neural underpinnings of trauma resilience versus susceptibility might be key to improve PTSD prevention and treatment. Maladaptive, intrusive trauma memories are a core symptom of PTSD. These memories are characterized by poor contextualization, suggesting impaired hippocampal recruitment in the trauma memory trace. This may

The dorsal dentate gyrus (dDG) plays a pivotal role in stress vulnerability and resilience. dDG granule cells interact with various interneuron subtypes, forming a complex local circuit essential for stress processing. Studies have shown differential activity in specific interneuron subtypes in response to stress, impacting coping mechanisms.This study examines the impact of two distinct categories of DG interneurons, chandelier and basket cells, on coping behavior. Ephrin A7 (EphA7) stabilizes synaptic terminals in basket cells, while Neurofascin (NF) facilitates axo-axonic synapse formation