Topic: sucrose preference test

The main objective of the study was to investigate the antidepressant like effect of curcumin in olfactory bulbectomized model of depression of male wistar albino rats through behavior screening tests. Bilateral olfactory bulbectomy was performed with rats anesthetized under ketamine (50 mg/kg/i.p.).Twenty male albino wistar rats, weighing 150–220 gm were randomly allocated into four groups (n=5)- Group A (control), Group B(olfactory bulbectomy;OB), Group C {vehicle (0.9% NS, 10 ml/kg) +olfactory bulbectomy,OB} & Group D {curcumin (40 mg/kg)+ olfactory bulbectomy;OB}.Behaviour screening te

Major Depressive Disorder (MDD) poses a global burden, affecting over 300 million individuals and presenting a significant therapeutic challenge due to the limited efficacy of conventional antidepressants. The investigation of rapid-acting antidepressants, exemplified by ketamine, has garnered attention, yet the intricate underlying processes remain incompletely understood.This study systematically evaluated the acute effects of ketamine (10 mg/kg, i.p.) and fluoxetine (3 x 10 mg/kg, i.p.) on depression-like behavior in animal models subjected to chronic restraint stress (CRS, 6 weeks) and chr

Major depressive disorder (MDD) is a great challenge for psychiatry with up to 40% of treatment-resistant patients. Therefore, non-pharmacological interventions such as different diets seem a promising tool. Ketogenic diet (KD) is a powerful tool for epilepsy and metabolic diseases while new clinical and animal studies show also its potential against mental disorders such as MDD, bipolar disorders and schizophrenia. Several neurobiological pathways have been suggested to mediate effect of KD for the brain and mental health with neurotrophic and neuroplasticity factor BDNF among them. Therefore

Depression, affecting 280 million people worldwide, is marked by a significant treatment gap. Current therapies with delayed onset of action fail to alleviate the symptoms in almost half of patients, often neglecting the cognitive deficits. This highlights the critical need for fast-acting antidepressants with memory-enhancing properties. HBK-15, a multimodal compound, previously demonstrated antidepressant-, anxiolytic-like and antiamnesic effects in rodents. Our study aimed to explore HBK-15's potential in reversing stress-induced behavioral abnormalities and elucidating its underlying mecha