Examining the response of activated microglia to MSC-derived EV obtained from various isolation protocols
Fabian Blessing, Lara Bieler, Eva Grasmann, Daniela Auer, Mario Gimona, Eva Rohde, Sebastien Couillard-Despres · FENS Forum 2024
At present, no effective therapies are available for traumatic spinal cord injury (SCI). Following the initial trauma, persistent inflammation exacerbates neuronal and functional losses. Our recent findings highlight the potential of acute treatment with MSC-derived extracellular vesicles (MSC-EVs) in mitigating inflammation and its consequential damages after SCI. However, with numerous protocols available for EV preparation from MSC-derived secretomes, we sought to identify the most efficacious method for generating EV preparations capable of reducing the pro-inflammatory polarization of mic
ePoster · Neuroscience