Topic: Toll-like receptors

Neuroinflammation mediated by toll-like receptors (TLRs) signaling pathway has a substantial role to morphine addiction. Αlpha-pinene is a member of the monoterpene family that has exhibited anti-inflammatory effects. This study aimed to examine the anti-inflammatory effects of alpha-pinene treatment on TLRs signaling pathway in the rat hippocampus after morphine dependence and withdrawal. Six groups of male Wistar rats were used in two categories, including dependent and withdrawal. Morphine (10 mg/kg) was intraperitoneally injected twice daily for 10 consecutive days to induce dependence. Al

Introduction: Epileptogenesis is the molecular and cellular process by which a healthy brain becomes an epileptic one. Some evidence suggests that the disruption of circadian rhythms may be impacting the epilepsy phenotype. However, whether the molecular clock is a key player in epileptogenesis remains to be elucidated. Here, we mapped for the first-time the hippocampal molecular rhythmicity of mice during epileptogenesis. Methods: Male adult C57BL/6 mice (n=5/group/Zeitgeber-Times [ZTs]) underwent intra-amygdala kainic acid-induced (i.a.KA) status epilepticus or control (i.a.PBS). From 24h af

Huntington’s disease (HD) is a genetic neurodegenerative disorder that can result in motor, mood and cognitive symptoms. HD pathophysiology has been linked to neuroinflammation, which is the presence of inflammatory mediators and reactive glial cells in the brain parenchyma. Many signalling pathways likely interact to propagate neuroinflammation and contribute to cell loss. Previous literature indicates that in the anterior cingulate cortex, cell loss and neuroinflammation are correlated with HD mood symptoms. This project gives insight into inflammation-related differential gene expression in

Innate Toll-like receptors (TLRs) play a critical role in activating microglia in various diseases of the CNS. Our study aimed to examine the widely unknown consequences of stimulation of TLR7/8, which are known to recognize single-stranded RNA (ssRNA), e.g. from viruses. For this, we conducted electrophysiological local field potential recordings of neuronal gamma-oscillations (30-70 Hz), biochemical assays, and immunofluorescence in rat organotypic hippocampal slice cultures. Our findings reveal that single exposure (48 h) to the TLR7/8 agonist Resiquimod (R848) induces the release of pro-in