Topic: urocortin 1 (UCN1)

ePoster: 2 ePosters

Centrally located transient receptor potential ankyrin 1 ion channel may exert diverse impact on the symptoms of posttraumatic stress disorder in mice

János Konkoly, Viktória Kormos, Balázs Gaszner, Dóra Zelena, Erika Pintér · FENS Forum 2024

Introduction: Transient receptor potential ankyrin 1 (TRPA1) is a non-selective cation channel expressed in the urocortin 1 (UCN1) positive neurons of the centrally projecting Edinger-Westphal nucleus (EWcp) having modulatory impact on stress adaptation. As post-traumatic stress disorder (PTSD) is triggered by disturbed stress adaptation, we hypothesized the regulatory role of EWcp/UCN1/Trpa1 neurons in PTSD.Methods: Male TRPA1 wild-type (WT) and knockout (KO) mice were exposed to two different models of PTSD. In single prolonged stress (SPS) paradigm, time spent immobility was measured during

ePoster · Neuroscience

Involvement of peptidergic Edinger-Westphal nucleus in the neurobiology of migraine

Ammar Al-Omari, Balázs Gaszner, Dóra Zelena, Kinga Gecse, Gergely Berta, Tünde Biró-Sütő, Péter Szocsics, Zsófia Maglóczky, Péter Gombás, Pintér Erika, Gabriella Juhász, Viktória Kormos · FENS Forum 2024

The urocortin 1 (UCN1)-expressing neurons of the centrally projecting Edinger-Westphal nucleus (EWcp) are affected by the circadian rhythm, hormonal changes, stress and pain that are known to trigger migraine. Here we aimed at investigating the possible role of EWcp in migraine neurobiology.RNAscope in situ hybridization (ISH) combined with immunostaining was used to examine the expression of calcitonin gene-related peptide (CGRP) receptor component (Crcp) in both mouse and human EWcp and dorsal raphe nucleus (DRN). Anterograde and retrograde tracing study investigated the neuroanatomical conn

ePoster · Neuroscience