Topic: Vascular endothelial growth factor

ALS is a progressive neurodegenerative disease characterised by the loss of motoneurons (MNs). Some MNs present a lower vulnerability to the disease, including neurons of the oculomotor system (OCM), compared to other cranial MNs (facial or hypoglossal). Vascular endothelial growth factor (VEGF) has shown the ability to protect MNs from degeneration. Overexpression of VEGF is involved in neuroprotection and delayed neurodegeneration of MNs. We have previously described a higher amount of VEGF in the extraocular neurons in control adult rats. The objective of this study in the murine SOD1G93A A

Peripheral nerve injury is an important health problem that threatens public health. The aim of this study is to investigate the effects of a biocellulose (BC) conduit and a biocellulose conduit impregnated with vascular endothelial growth factor (VEGF) on peripheral nerve regeneration. Biocellulose derived from Gluconacetobacter xylinus cell culture was impregnated with 0.2 µm/ml VEGF and formed into conduits. Unilateral 8-millimeter rat sciatic nerve defects were repaired using biocellulose conduit, VEGF-impregnated biocellulose conduit, and an autograft. Walking analysis was conducted at sp

A functional microvasculature is a paramount target for accomplishing long-lasting engineered tissues. The challenge in neuroscience is building a microvascular network that could mimic the neurovascular unit, allowing the central nervous system (CNS) vitality. The vessels invade the CNS extracellular matrix (ECM) during embryogenesis. Biomaterials can offer the structural guidance and signaling pathways to recapitulate this complex process. Our project (THOR – European Innovation Council-Pathfinder Programme, Grant Agreement number 101099719) uses high-performance functionalized silk fibers w