Utilizing Invasive Recording and Stimulating Opportunities in Humans to Advance Neural Circuitry Understanding of Mental Health Disorders (R21 Clinical Trial Optional)

NIMH supports exploratory research using opportunities for invasive recording and stimulation in humans to understand neural circuits relevant to mental health disorders. Projects should connect measurements or causal interventions with mechanistic questions about brain function. This R21 mechanism provides up to USD 275,000 in direct costs over two years, with no more than USD 200,000 in either year. The next deadline for new applications is 16 October 2026, at 5 p.m. in the applicant organisation’s local time. Therapeutic device intervention trials are outside this call’s intended scope.

Eligible higher-education, nonprofit, for-profit and other organisations listed in the NOFO, including non-US organisations, apply through their institution. Required institutional registrations and the NOFO-specific research conditions apply.