Harnessing the CRISPR toolbox to engineer biology
Video · 1 h 3 min · Oct 29, 2020
Randy Platt, ETH Zurich
From CRISPR-Cas Immunity to Targeted Genome Editing and Beyond
Genetic Engineering, Molecular Biology, Molecular Genetics and seminar by Virginijus Šikšnys, Professor, Institute of Biotechnology, Vilnius
Hosted by Collège de France
Friday 17:30–18:30 Paris (GMT+1)
Recording available
Amphithéâtre Maurice-Halbwachs, Site Marcelin-Berthelot · In person
Abstract
Virginijus Šikšnys traces genome-editing tools to bacterial antiviral defence. Programmable CRISPR-Cas nucleases offer powerful ways to alter DNA, but delivery, unintended effects, immune interactions and insertion efficiency remain challenges. The lecture discusses compact TnpB nucleases and how further study of defence systems may reveal useful enzymatic functions.
Topics
genome-editing toolsbacterial antiviral defenceCRISPR-Cas nucleasesDNAdeliveryunintended effectsimmune interactionsinsertion efficiency
Show 2 more topics
TnpB nucleasesdefence systems
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