Hippocampal replays appear after a single experience and slow down with subsequent experience as greater detail is incorporated
Schedule
Friday, July 31, 2020
15:00 UTC
Alice Berners-Lee
Johns Hopkins / UC Berkeley (David Foster's lab)
Host: Oxford WINeuro
Recording
Open recording
Event Information
Recording
Available
Host
Oxford WINeuro
Duration
70 minutes
Abstract
The hippocampus is implicated in memory formation, and neurons in the hippocampus take part in replay sequences, time-compressed reactivations of trajectories through space the animal has previously explored. These replay sequences have been proposed to be a form of memory for previously experienced places. I will present work exploring how these replays appear and change with experience. By recording from large ensembles of hippocampal neurons as rats explored novel and familiar linear tracks in various experiments, we found that hippocampal replays appear after a single experience and slow down with subsequent experience as greater detail is incorporated. We also investigated hover-and-jump dynamics within replays that are associated with the slow gamma (25-50Hz) oscillation in the LFP and found that replays slow down by adding more hover locations, corresponding to depiction of the behavioral trajectory with increased resolution. Thus, replays can reflect single experiences, and be rapidly modified by subsequent experience to incorporate more detail, consistent with their proposed role as a basic mechanism of hippocampally dependent memory.
Topics
Related Seminars
SeminarSeminarSeminar
Deciphering the Dynamics of the Unconscious Brain under General Anesthesia
Stanford Neurosciences Seminar Series talk by Emery Brown (Massachusetts Institute of Technology, Neuroscience Statistics Research Lab) on deciphering the dynamics of the unconscious brain under…
Upcoming · Sep 17, 2026
Wu Tsai Neurosciences Institute, Stanford University
Engineering human myelination in vitro: Mechanobiologically compatible platforms for CNS drug discovery
UCL Department of Neuroinflammation Seminar by Professor Emad Moeendarbary (Professor of Cell Mechanics and Mechanobiology, UCL Mechanical Engineering) on how biophysical factors such as substrate…
Upcoming · Sep 30, 2026
UCL Queen Square Institute of Neurology — Department of Neuroinflammation
Colloquium on the Brain and Cognition with Christopher Harvey, PhD, Harvard University
Picower Institute Colloquium on the Brain and Cognition featuring Christopher Harvey, PhD, of Harvard University, held in Singleton Auditorium (46-3002) at MIT Building 46, 43 Vassar Street.
Upcoming · Oct 1, 2026
The Picower Institute for Learning and Memory, MIT
Related Job Opportunities
JobJobJob
PhD Studentship: Mitochondrial Metabolism and Novel Therapeutic Strategies for Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) (Fixed Term)
A fully funded University of Cambridge PhD studentship, supported by Novo Nordisk, will investigate how mitochondrial metabolism changes during metabolic dysfunction-associated steatotic liver…
Posted Aug 10, 2026
Research Associate (Fixed Term)
Kathy Niakan's laboratory at the Loke Centre for Trophoblast Research is recruiting a postdoctoral researcher to study early lineage specification in human pre- and early post-implantation embryos.…
Posted Aug 11, 2026
Cambridge, United Kingdom
Research Assistant/Associate (Fixed Term)
A fixed-term research position in the laboratories of Ole Paulsen and Jasper Poort will study neural mechanisms of visual learning in mice. The project combines patch-clamp electrophysiology…
Posted Aug 11, 2026
Cambridge, United Kingdom