Unique features of oxygen delivery to the mammalian retina
Schedule
Tuesday, February 7, 2023
14:00 UTC
Robert Linsenmeier
Professor Emeritus
Northwestern University
Host: Mathematical and Computational Ophthalmology
Recording
Open recording
Event Information
Recording
Available
Host
Mathematical and Computational Ophthalmology
Duration
70 minutes
Abstract
Like all neural tissue, the retina has a high metabolic demand, and requires a constant supply of oxygen. Second and third order neurons are supplied by the retinal circulation, whose characteristics are similar to brain circulation. However, the photoreceptor region, which occupies half of the retinal thickness, is avascular, and relies on diffusion of oxygen from the choroidal circulation, whose properties are very different, as well as the retinal circulation. By fitting diffusion models to oxygen measurements made with oxygen microelectrodes, it is possible to understand the relative roles of the two circulations under normal conditions of light and darkness, and what happens if the retina is detached or the retinal circulation is occluded. Most of this work has been done in vivo in rat, cat, and monkey, but recent work in the isolated mouse retina will also be discussed.
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