Synthetic Chemistry ePosters

Alzheimer's disease (AD) is a complex ailment of uncertain origin. The available treatments, restricted to cholinesterase inhibitors and N-methyl-D-aspartate receptor (NMDAR) antagonists, merely relieve symptoms. Given the ineffectiveness of single-target therapies, a more promising approach involves a rational…

Alzheimer’s disease (AD) accounts for 80% of dementia cases worldwide. The major histopathological marker is the presence of extracellular senile plaques composed of beta amyloid peptide aggregates. Beta amyloid peptide accumulation leads to oxidative stress, which through lipid peroxidation induces the formation of…

The heptapeptide angiotensin (Ang 1-7: Asp-Arg-Val-Tyr-Ile-His-Pro) is one of the main endogenous components of the protective arm of the renin-angiotensin system (RAS). Acting on the Mas receptor (MasR), it exhibits vasodilator, antiproliferative, anti-inflammatory, and neuroprotective effects. To improve its…

Quercetin is a polyphenolic flavonoid compound with a proven wide range of biological activities including neuroprotective effects in neuronal injury/neurodegenerative disease models which is related with its high antioxidant properties. However, due to its low water-solubility, poor bioavailability, rapid clearance,…

Alzheimer's disease (AD) is a progressive neurodegenerative disease and the most common cause of dementia in the elderly inviduals, with a prevalence twice as high in the female population. [1] Acetylcholine inhibitors (AChEIs) are one of the most investigated class of chemical compounds in treatment of AD. As a part…