…spines, advanced microscopy and novel biosensors, the project examines how calcium release from internal stores contributes to dendritic calcium signals, how PKA and PKC activity interact with them, whether these interactions explain two modes of spine growth, where retrograd
Biosensors
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Melody is hiring a bioelectronics engineer to integrate protein biosensors, surface chemistry, hydrogels, membranes, and optical or electrochemical readout hardware into continuous molecular-monitoring technology. The role owns wetware integration strategy, diagnostic experimentation, directed-evolution workflows, materials development, instrumentation, and automation for real-world biosensing and eventual in-vivo studies.
Melody is recruiting a protein engineer to create biosensors from allosteric switches, signaling motifs, reporter proteins, site-specific chemical modifications, and bioelectronic interfaces. The role spans construct design, wet-lab screening, device integration, experimental or computational protein design, and mentoring within a continuous molecular-monitoring program.
…include carbon capture, remediation, biosensors and waste-based biomanufacturing. Responsibilities include teaching, mentoring and service. Full consideration is by 1 November 2026, followed by continued review until filled.
…Projects may develop biosensors, integrate living components into physical systems, adapt organisms to extreme environments, or devise new fabrication methods. The scientist will lead or collaborate on interdisciplinary projects, communicate results and maintain research documentation. This full-time, on-site role is based in New York City, with a stated annual compensation range of US$121,000–151,000. Instead of a cover letter, applicants must upload a project proposal
…biological systems and may involve biosensors, biomanufacturing, synthetic-biology platforms, gene editing, AI or computational biology. Projects must have total eligible costs of £750,000
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Exploring noradrenergic signaling and sleep patterns in prodromal stages of Alzheimer’s disease mouse models
The onset of Alzheimer disease (AD) and of abnormal sleep patterns are both signaled by initially minute but ultimately disastrous physiological malfunctions of the brain. Among these, the Locus Coeruleus (LC) belongs to the primary brain areas that show such malfunctions in the early stages of AD. The LC generates large noradrenaline (NA) signals that are key for the architecture of sleep in mice. In contrast, how LC malfunctions relate to sleep disturbances in AD remains unknown.We explore the real-time functionality of the noradrenergic system during AD’s prodromal phase in an established A
Nanobody-based FRET biosensors to quantify endogenous group I metabotropic glutamate receptors
G protein-coupled receptors (GPCR) are the largest family of membrane proteins in the human genome and represent targets of about 30% of the marketed drugs. Among GPCRs, metabotropic glutamate receptors (mGluRs) are interesting targets as they regulate neuronal excitability and synaptic transmission in the central nervous system, and are involved in various brain diseases. Due to the lack of specific tools, their specific subunit composition in native tissues is still difficult to determine. Finding highly specific tools to target each mGluR subunit is still a challenge that single domain anti