Brain ageing

Two research positions investigate why individuals differ in their resilience to brain ageing. Emi Ling’s laboratory combines molecular neurobiology, biochemistry and single-cell omics to identify mechanisms associated with lasting cognitive health. Researchers lead projects, publish findings and mentor junior colleagues. Appointments are annual and renewable after evaluation, with role-specific limits of five years for postdoctoral researchers and seven for research scientists. Applicants need a relevant PhD; the postdoctoral category covers those within five years of their doctorate. Recruit

Support computational studies of why individuals differ in normal brain ageing. The technical role analyses large biological datasets, including single-cell genomic and transcriptomic measurements.

Brain ageing in mice leads to the progressive appearance of degenerative granular structures frequently referred to as “PAS granules” because of their positive staining with periodic acid-Schiff (PAS). It has been reported that these granules contain neo-epitopes that can be recognised by natural IgM auto-antibodies, and proposed that they intervene in a brain cleaning mechanism. Some preliminary studies seem to indicate that these neo-epitopes are also present in other structures than PAS granules, so the aim of this work has been to study and characterize the presence of neo-epitopes in mice

…deep learning techniques for studying brain ageing and prognosis in dementia, will be addressed. Also the concept of deep imaging, a full integration of medical imaging and machine learning, will be discussed. Finally, I will address the challenges of how to successfully integrate these technologies in daily clinical workf