AACR Annual Meeting 2027
The American Association for Cancer Research's flagship annual meeting, themed 'Delivering Discovery Science: The Bridge to Breakthrough Therapeutics', at the Orange County Convention Center in Orlando, Florida.
Pre-doctoral Research Bursary
Cancer Research UK offers short-term support for clinicians, nurses and allied health professionals to gain early-career cancer-research experience and generate preliminary data before applying for a PhD or MD fellowship.
Effect of the intratumoral microbiota on spatial and cellular heterogeneity in cancer
Radiopharmaceutical evaluation of novel bifunctional chelators and bioconjugates for tumour imaging and therapy
Bispidines (3,7-diazabicyclo[3.3.1]nonane) and their derivatives act as bifunctional chelators (BFC), combining the advantages of multidentate macrocyclic and acyclic ligands e.g. high kinetic inertness, rapid radiolabelling under mild conditions. This bicyclic chelator system shows a great diversity in terms of its denticity and type of functional groups, yielding a wide range of multidentate ligands that can bind a variety of different metal ions. In addition, they allow a facile functionalisation of targeting molecules such as peptides, peptidomimetics, and bispecic antibodies. Herein, examples of various bispidine complexes labelled with [64Cu]Cu2+, [111In]In3+, [ 177Lu]Lu3+ or [ 225Ac]Ac3+ will be presented which provide a picture of how different substituents inuence the coordination mode. Target-specic radiolabelled bispidine-based conjugates (e.g. peptides, antibody fragments, antibodies) investigated in vivo by positron emission or single-photon emission computed tomography will be presented and discussed in terms of their suitability for nuclear medicine applications.