CRISPR screening

…cell engineering and multiplexed CRISPR screening with single-cell multi-omics and AI modelling to build cell-type-specific disease models for therapeutic discovery in oncology, neurodevelopmental and neurodegenerative disorders and metabolic disease. The postdoc will engineer, differentiate and functionally characterise human iPSCs, design and run

…The lab integrates CRISPR-based functional genomics (genome-wide and custom screening libraries), epigenetic profiling including DNA methylation and hydroxymethylation (5mC/5hmC), next-generation sequencing, chemical biology and in vivo mouse models to identify and characterise therapeutic targets, including regulators of androgen receptor signalling, and to combine genetic, epigenetic and small-molecule perturbations t