Diabetes

…Diabetes was induced by a single intraperitoneal dose of streptozotocin (55 mg/kg). The animals were divided into six groups: control/vehicle;

…disorders such as obesity and diabetes. The compound has anti-inflammatory properties and has been shown to improve insulin sensitivity and lipid metabolism. Its weight loss properties are attributed to an improvement in leptin sensitivity, most likely by targeting neural circuits in the hypothalamus that control food intake and appetite. Despite extensive research, the precise mechanism of action remains elusive. In this study, w

Diabetes is a common metabolic disease whose hyperglycemic state can induce various complications, including central nervous system complications. There is evidence which suggests that oxidative stress has a key role in the pathogenesis of diabetes and its complications. Autophagy is one of the main routes to eliminate damaged components in cells in response to oxidative stress. However, excessive autophagy causes a distinct type of cell death involved in the pathogenesis of multiple diseases, such as diabetes. This study aimed to investigate the effect of melatonin on the autophagy in the pre

…Likewise, diabetes and obesity, two metabolic illnesses, are risk factors for AD. These two diseases are associated with an expansion of visceral adipose tissue (VAT). Here, we hypothesize that the visceral adipose tissue may serve as a key communicator organ between the brain and peripheral metabolic disorders and affecting both types of disorders.We used histological s

Diabetes has a systemic effect on the metabolism and can be linked to higher risks of severe medical conditions, such as ischemic stroke. Hyperglycemia leads to more extensive cerebral damage during stroke and, as a result, to more severe consequences. One of the main damaging factors of the stroke is the reactive oxygen species generation occurring in mitochondrial respiratory chain (electron transport chain, ETC). We used in vivo Raman microspectroscopy with the chronic cranial windows implantation to assess the redox state of mitochondria ETC in neurons of awake mice under normal and hyperg

Metabolic disorders like diabetes and obesity markedly elevate the risk of neurodegenerative diseases. While certain medications used to manage these conditions show neuroprotective potential, their exact mechanisms of action remain elusive. Here, we propose the utilization of brain histology in a mouse prion model as an effective approach for drug screening in dementia and for exploring the cellular mechanisms of neuroprotection offered by anti-diabetic drugs. Our primary objective was to establish the morphological criteria for brain pathology in prion-infected mice. To achieve this, C57BL/6

Diabetes is a progressive metabolic disease that can severely damage several organs, including the central nervous system. It has been suggested that diabetes can induce cognitive dysfunction due to expression changes of excitatory neurotransmission mediated by N-methyl-D-aspartate (NMDA) receptors. In addition, diabetes is associated with imbalances in the regulation of intracellular Ca2+, which leads to neuronal damage and, ultimately, a decline in cognitive abilities. Moreover, Type 1 diabetes patients have higher glutamate levels in their brains, which can be used as an early marker of dia

…secretion and increases the risk of diabetes and its complications, including anxiety. We aimed to study the effects of reduced daily light exposure on diabetes-associated anxiety-like behavior and brain oxidative stress in streptozotocin-treated rats. Male Wistar rats were divided into the following groups: 1. control (C12/12), saline-treated group with light/dark cycle 12/12h; 2. saline-treated group on light/dark

…Diabetes is one of the stro

The increasing prevalence of obesity and type 2 diabetes (T2D) and associated morbidity and mortality emphasizes the need for a more complete understanding of the mechanisms mediating energy homeostasis to accelerate the identification of new medications. Recent reports indicate that obesity medication, 5-hydroxytryptamine (5-HT, serotonin)2C receptor (5-HT2CR) agonist lorcaserin improves glycemic control in association with weight loss in obese patients with T2D. We examined whether lorcaserin has a direct effect on insulin sensitivity and how this effect is achieved. We clarify that lorcaser