Topic: diabetes

Lead research on stroke mechanisms and treatment, including experimental work connecting diabetes, GLP-1-related pathways and cerebrovascular disease with clinical or epidemiological studies. The professorship combines scientific leadership, research development and teaching within Karolinska Institutet. This is a permanent, full-time appointment. The extended application period closes on 14 October 2026.

The increasing prevalence of obesity and type 2 diabetes (T2D) and associated morbidity and mortality emphasizes the need for a more complete understanding of the mechanisms mediating energy homeostasis to accelerate the identification of new medications. Recent reports indicate that obesity medication, 5-hydroxytryptamine (5-HT, serotonin)2C receptor (5-HT2CR) agonist lorcaserin improves glycemic control in association with weight loss in obese patients with T2D. We examined whether lorcaserin has a direct effect on insulin sensitivity and how this effect is achieved. We clarify that lorcaser

Alzheimer’s disease (AD) is a complex disorder and multiple molecular mechanisms are involved in AD onset and progression. Recent evidences have suggested that metabolic alterations are an important pathological feature in AD. Likewise, diabetes and obesity, two metabolic illnesses, are risk factors for AD. These two diseases are associated with an expansion of visceral adipose tissue (VAT). Here, we hypothesize that the visceral adipose tissue may serve as a key communicator organ between the brain and peripheral metabolic disorders and affecting both types of disorders.We used histological s