Gene editing

…synthetic-biology platforms, gene editing, AI or computational biology. Projects must have total eligible costs of £750,000

A January–June 2027 placement developing and optimising gene editing systems for therapeutic programmes. Work includes generating reagents and small-scale mRNA preparations, maintaining mammalian cells, transfecting cells, isolating genomic DNA and preparing samples for sequencing. The student collaborates with research scientists on experimental design, data interpretation and presentations. The position is based in Cambridge, Massachusetts.

…The student generates and interprets experimental data and may also contribute to cloning, plasmid preparation and in vitro transcription. Work supports the evaluation of mRNA reagents for gene editing research.

Lead biostatistics and the wider biometrics function for Prime Medicine’s gene editing clinical programmes. The role develops trial designs, endpoints, dose-escalation strategies and analysis plans while overseeing clinical data management and statistical programming partners. It supports regulatory interactions and quantitative decisions from protocol development through submission, and builds the organisation’s biometrics capabilities in Cambridge, Massachusetts.

Synthesise, purify and characterise modified oligonucleotides for gene editing and targeted delivery research. The role uses automated solid-phase synthesis, preparative chromatography, LC-MS and bioconjugation to produce RNA/DNA reagents and small-molecule or antibody conjugates for experimental studies. This full-time laboratory role is fully onsite in South Boston, Massachusetts.

…Paula Chen and Kiho Lee examine gene editing as a way to reduce susceptibility and improve animal health. Chen presents genome-editing approaches to preventing poultry disease; Lee discusses improving the genetic value of pigs through gene-editing technology. The programme connects these strategies to the continuing challenges posed by viral outbreaks, evolving PRRS variants and debate about vaccination as a control measure.

…and approaches connected with gene editing, placing these developments in the broader biology of RNA and its possible role in the origins of life.

Jennifer Doudna discusses how CRISPR changed gene editing and what might come next. The conversation examines emerging applications, technical limitations and the ethical choices involved in altering genetic material, including how scientific progress can be paired with responsible use.

…Data from acute gene-editing based knockdown, followed by functional assays, will be presented.

…and discuss two topics: (i) the use of gene editing as an approach to therapy and (ii) the role of MECP2 in gene expression (i) The mutation of the X-linked MECP2 gene is causative for the disease. In a female patient, every cell has a wt copy that is, however, in 50% of the cells located on the inactive X chromosome. We have used epigenetic gene editing tools to activate the wt MECP2 allele on the inactive X

…of Alzheimer's disease (AD), but using genetic techniques such as gene editing these two types of cells in vivo is challenging as there are no efficient and specific vector tools to deliver genes to these cells. So we proposed some methods to achieve this goal. By combining viral libraries with evolutionary screening, we will screen vector tools that can specifically and efficiently infect this type of cells. First, these tools will make it easier for scientists to precisely manipulate c