Topic: gene editing

Highly pathogenic avian influenza and porcine reproductive and respiratory syndrome impose major disease and economic burdens on poultry and swine production. Paula Chen and Kiho Lee examine gene editing as a way to reduce susceptibility and improve animal health. Chen presents genome-editing approaches to preventing poultry disease; Lee discusses improving the genetic value of pigs through gene-editing technology. The programme connects these strategies to the continuing challenges posed by viral outbreaks, evolving PRRS variants and debate about vaccination as a control measure.

This business-led collaborative research and development competition will fund new engineering-biology products, processes and services and de-risk technologies with strong market potential. Projects may address health, agriculture and food, chemicals and materials, low-carbon fuels, waste and environment, or cross-cutting technology and service development. The central innovation must purposefully engineer biological systems and may involve biosensors, biomanufacturing, synthetic-biology platforms, gene editing, AI or computational biology. Projects must have total eligible costs of £750,000

Jeff Coller explains how messenger RNA carries information from DNA to the machinery that produces proteins and how researchers are learning to use it therapeutically. The conversation covers vaccination, tailored treatments and approaches connected with gene editing, placing these developments in the broader biology of RNA and its possible role in the origins of life.

Jennifer Doudna discusses how CRISPR changed gene editing and what might come next. The conversation examines emerging applications, technical limitations and the ethical choices involved in altering genetic material, including how scientific progress can be paired with responsible use.

The development of the iPS cell technology has revolutionized our ability to study development and diseases in defined in vitro cell culture systems. The talk will focus on Rett Syndrome and discuss two topics: (i) the use of gene editing as an approach to therapy and (ii) the role of MECP2 in gene expression (i) The mutation of the X-linked MECP2 gene is causative for the disease. In a female patient, every cell has a wt copy that is, however, in 50% of the cells located on the inactive X chromosome. We have used epigenetic gene editing tools to activate the wt MECP2 allele on the inactive X