Topic: genome editing

Develop new gene insertion approaches and engineered immune-cell therapies in the CRISPR-X research team. The scientist designs genome editing experiments and CAR-T constructs, evaluates molecular and cellular outcomes, and develops translational assays for new disease indications. Methods include cloning, quantitative and digital PCR, sequencing and primary-cell engineering. This full-time role is fully onsite in South Boston, Massachusetts.

Neural stem cells (NSCs) generate new neurons throughout life. We use imaging-, genome editing-, and transgenesis-based approaches as well as cellular models of human diseases using pluripotent embryonic cells to study the molecular and cellular framework of NSC biology in the developing and adult brain. Aim of our research is to understand how physiologic and disease-associated alterations of neurogenesis are translated into stem cell-associated plastic changes in the developing and adult brain on a molecular, cellular, and behavioral level.