Pluripotent stem cells

Research in the Gamm laboratory uses human pluripotent stem cells to study retinal development and degeneration and to develop cell-based rescue or replacement approaches. The intern will culture and differentiate cells, characterize retinal tissues, and learn sectioning, immunohistochemistry and molecular methods. This full-time Waisman Center role lists a salary of $46,109 and a 15 January 2027 start. Apply with a résumé and cover letter to Lindsey Jager at ldjager@wisc.edu, using the subject “Research Intern-Development and Disease Modeling”.

…generate defined cell populations from pluripotent stem cells for mechanistic studies and tissue modelling. We aim to understand how developmental history shapes blood and vascular cell identity and function, and to apply this knowledge to build improved vas

…neurons within the central nervous system. ALS exhibits significant heterogeneity, demonstrating variability in clinical presentation, disease progression, and the neural populations affected. This diversity has historically complicated identifying disease mechanisms and devising universally effective treatments. Organoids derived from patient pluripotent stem cells offer an innovative platform to investigate ALS, by recapitulating the multicellular comp

…to unravel Gαq regulation in neural cells, focusing on surface marker expression. To study surface marker regulation, CRISPR-mediated Gαq knockouts were generated in Lund human mesencephalic cells (LUHMES; neural) and pluripotent stem cells (embryonic).

…and its size, we use a human model system in a dish, called cerebral organoids. These 3D tissues are generated from pluripotent stem cells through neural differentiation and a supportive 3D microenvironment to generate organoids with the same tissue architecture as the early human fetal brai