Topic: probiotics

The gut microbiome plays an integral part in neurodegeneration through its direct interaction with the autonomic nervous system (ANS) via the vagal nerve. The aim of this pilot study is to investigate changes in ANS function in patients with mild Alzheimer’s Disease (AD) following administration of probiotics, compared to placebo (no active probiotics). Patients with mild AD (MMSE: 19-23) who fulfil all eligibility criteria were enrolled on the study and randomly assigned to take probiotics or placebo (control) for 16 weeks. We collected various data at baseline and study completion (weeks 0 &

Autism spectrum disorders (ASDs) are heterogeneous neurodevelopmental disorders characterized by impairments in social behavior and communication. Traditional research on the biology of ASDs has focused on the central nervous system (CNS), aiming to identify brain regions, molecular mechanisms, and genetic mutations associated with ASDs. However, an increasingly holistic approach to ASDs demonstrated that there is comorbidity with immune and gastrointestinal (GI) dysfunctions. It is now accepted that there is a bidirectional communication between the gut and the brain, with the microbiota play

We live in a microbial world with trillions of microbes in and around us helping to digest food and regulating the immune system. Emerging data also suggest the critical influence of the gut microbiota on the brain impacting on behaviour and mental health. For example, the absence of gut microbes in experimentally derived germ-free mice results in impaired behaviours including reduced or complete lack of social interactions. Conversely, supplementation of deficient gut microbiota with probiotics and/or specific bacterial strains can restore social function. Despite a surge in such correlative

The intrauterine milieu significantly influences the future health trajectory of offspring, wherein adverse prenatal conditions can induce aberrant fetal neurodevelopment with enduring consequences. Prenatal stress represents a notable adverse condition known to affect offspring health detrimentally, often correlated with dysregulations in gut microbiome composition. Therefore, we aim to investigate the impact of prenatal stress on offspring neurodevelopment and to evaluate the potential mitigative role of probiotics. Randomly chosen pregnant female Wistar rats underwent daily restraint stress