Adolescent maturation of cortical excitation-inhibition balance based on individualized biophysical network modeling
Amin Saberi, Kevin Wischnewski, Kyesam Jung, Leon Lotter, H. Schaare, Tobias Banaschweski, Gareth Barker, Arun Bokde, Sylvane Desrivières, Herta Flor, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Rüdiger Brühl, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Eric Artiges, Frauke Nees, Dimitri Papadopoulos Orfanos, Herve Lemaitre, Luise Poustka, Sarah Hohmann, Nathalie Holz, Christian Baeuchl, Michael Smolka, Nilakshi Vaidya, Henrik Walter, Robert Whelan, Gunther Schumann, Tomas Paus, Juergen Dukart, Boris Bernhardt, Oleksandr Popovych, Simon Eickhoff, Sofie Valk · Bernstein Conference 2024
Background: The balance of excitation and inhibition (E-I) is a key functional property of cortical microcircuits [1] which changes through lifespan. Adolescence is considered a crucial period for the maturation of E-I balance [2,3]. This has been primarily observed in animal studies, and human in vivo evidence on adolescent maturation of the E-I balance at an individual level is limited. Here, we investigated an in vivo marker of regional E-I balance in human adolescents based on individualized biophysical network models. Methods: Regional E-I balance was estimated using large-scale simulati