Topic: voxel-based morphometry

Aim Adverse childhood experiences (ACEs) are related to worse mental health outcomes and reduced grey matter volume (GMV) in dorsolateral prefrontal cortex (DLPFC), amygdala (AMY), and hippocampus (HC), which has mostly been observed in samples of 12–50-year-old individuals. We hypothesize that these anomalies persist in middle- to old-age and brain structure (ROIs: HC, AMY, DLPFC) mediates the association of ACE with anxiety and depression symptoms. Methods The study uses data from the Hamburg City Health Study, which randomly sampled adults between 45–74 years (N=2,525) and tested them for a

The aim of this study was to investigate whether grey matter densities (GMD) in the brain associate with speech disfluency in 120 (65M, 55F) 5-year-old children. Speech disfluency, which was quantified via audio recordings, was measured as a continuous variable, covering a broad spectrum of disfluencies observed in a sample of children participating in the FinnBrain Birth Cohort study. Structural magnetic resonance imaging (MRI) and voxel-based morphometry (VBM) of the whole brain was utilised to examine the associations between GMD and speech disfluency. We found negative associations between

Maternal prenatal distress is an important contributor to child neurodevelopmental trajectories but relatively few studies have explored the effect of distress exposure longitudinally across the perinatal period. The aim of this study was to investigate associations between exposure to pre- and postnatal maternal distress and child brain development in 5-year-olds. Mother-child dyads (n=173) were recruited from the FinnBrain Birth Cohort study. Maternal distress was quantified with composite scores of the Edinburgh Postnatal Depression Scale (EPDS) and the anxiety subscale of the Symptom Check

Subjective cognitive decline (SCD) manifests as a self-perceived deterioration in memory and thinking abilities, undetectable through objective tests, but which is considered as an early at-risk phase for developing mild cognitive impairment (MCI) and Alzheimer’s disease (AD). Understanding the brain structural and functional changes that underlie this condition is important in developing interventions that would prevent the evolution to dementia. Neuroimaging structural and resting state studies comparing SCD individuals with healthy controls (HC) have reported inconsistent results. Therefore