Fully-funded PhD studentship: Unmasking mechanisms of resistance to KRAS inhibition across pancreatic cancer genetic profiles

Investigate resistance to KRAS inhibition across genetically distinct pancreatic cancers. The doctoral project studies tumour-cell and stromal mechanisms, including fibroblast effects, using organoid transplantation, mouse models, CRISPR, single-cell sequencing, flow cytometry and spatial methods. It seeks evidence for rational combination therapies and begins in October 2027.

UK and overseas applicants are eligible. Prior laboratory or industry research experience and willingness to work with mouse models throughout the PhD are required; relevant cell-culture and molecular-biology experience is advantageous.