Redox and mitochondrial dysregulation in epilepsy
Schedule
Wednesday, September 21, 2022
18:00 UTC
Manisha Patel
Prof
University of Colorado
Host: Clinical and Experimental Epilepsy
Recording
Open recording
Event Information
Recording
Available
Host
Clinical and Experimental Epilepsy
Duration
70 minutes
Abstract
Epileptic seizures render the brain uniquely dependent on energy producing pathways. Studies in our laboratory have been focused on the role of redox processes and mitochondria in the context of abnormal neuronal excitability associated with epilepsy. We have shown that that status epilepticus (SE) alters mitochondrial and cellular redox status, energetics and function and conversely, that reactive oxygen species and resultant dysfunction can lead to chronic epilepsy. Oxidative stress and neuroinflammatory pathways have considerable crosstalk and targeting redox processes has recently been shown to control neuroinflammation and excitability. Understanding the role of metabolic and redox processes can enable the development of novel therapeutics to control epilepsy and/or its comorbidities.
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