Cell Bio 2026 - An ASCB|EMBO Meeting
Joint ASCB|EMBO meeting at the San Diego Convention Center bringing together the cell biology community to share scientific discoveries, network with colleagues across career stages, and explore new research areas and methodologies.
EMBO Workshop: Organelle dynamics in health and disease: bridging molecules to organisms
This EMBO Workshop connects organelle contact sites and cytoskeletal interactions with metabolism, signalling, and trafficking, and examines their relevance to neurodegeneration, cancer, and other diseases.
How do protein-RNA condensates form and contribute to disease?
In recent years, it has become clear that intrinsically disordered regions (IDRs) of RBPs, and the structure of RNAs, often contribute to the condensation of RNPs. To understand the transcriptomic features of such RNP condensates, we’ve used an improved individual nucleotide resolution CLIP protocol (iiCLIP), which produces highly sensitive and specific data, and thus enables quantitative comparisons of interactions across conditions (Lee et al., 2021). This showed how the IDR-dependent condensation properties of TDP-43 specify its RNA binding and regulatory repertoire (Hallegger et al., 2021). Moreover, we developed software for discovery and visualisation of RNA binding motifs that uncovered common binding patterns of RBPs on long multivalent RNA regions that are composed of dispersed motif clusters (Kuret et al, 2021). Finally, we used hybrid iCLIP (hiCLIP) to characterise the RNA structures mediating the assembly of Staufen RNPs across mammalian brain development, which demonstrated the roles of long-range RNA duplexes in the compaction of long 3’UTRs. I will present how the combined analysis of the characteristics of IDRs in RBPs, multivalent RNA regions and RNA structures is required to understand the formation and functions of RNP condensates, and how they change in diseases.
From the cell biology of synaptic plasticity to SFARI
2nd In-Vitro 2D & 3D Neuronal Networks Summit
The event is open to everyone interested in Neuroscience, Cell Biology, Drug Discovery, Disease Modeling, and Bio/Neuroengineering! This meeting is a platform bringing scientists from all over the world together and fostering scientific exchange and collaboration.
2nd In-Vitro 2D & 3D Neuronal Networks Summit
The event is open to everyone interested in Neuroscience, Cell Biology, Drug Discovery, Disease Modeling, and Bio/Neuroengineering! This meeting is a platform bringing scientists from all over the world together and fostering scientific exchange and collaboration.
An open-source experimental framework for automation of cell biology experiments
Modern biological methods often require a large number of experiments to be conducted. For example, dissecting molecular pathways involved in a variety of biological processes in neurons and non-excitable cells requires high-throughput compound library or RNAi screens. Another example requiring large datasets - modern data analysis methods such as deep learning. These have been successfully applied to a number of biological and medical questions. In this talk we will describe an open-source platform allowing such experiments to be automated. The platform consists of an XY stage, perfusion system and an epifluorescent microscope with autofocusing. It is extremely easy to build and can be used for different experimental paradigms, ranging from immunolabeling and routine characterisation of large numbers of cell lines to high-throughput imaging of fluorescent reporters.
Role of Tunneling Nanotubes (TNTs) in the spreading of amyloid proteins in neurodegenerative diseases
On being the right size: Is the search for underlying physical principles a wild-goose chase?
When was the last time you ran into a giant? Chances are never. Almost 100 years ago, JBS Haldane posed an outwardly simple yet complex question – what is the most optimal size (for a biological system)? The living world around us contains a huge diversity of organisms, each with its own characteristic size. Even the size of subcellular organelles is tightly controlled. In absence of physical rulers, how do cells and organisms truly “know” how large is large enough? What are the mechanisms in place to enforce size control? Many of these questions have motivated generations of scientists to look for physical principles underlying size control in biological systems. In the next edition of Emory's Theory and Modeling of Living Systems (TMLS) workshop series, our panel of speakers will take a close look at these questions, across the entire scale - from the molecular, all the way to the ecosystem.