Lipid metabolism

The complexity of neurodegenerative processes and the human nervous system hinder progress towards a comprehensive understanding of both. Much of our advancements in understanding disease has been through the use of human post-mortem tissues. As these are only representative of the end stage of life, it is difficult to differentiate between chronic long-term consequences of disease (ie, neurofibrillary tangles) and potential regulators which directly drive pathological processes. Using small animal model systems has limitations resulting in high failure to translate directly from rodent-derive

…that diet-induced obesity dysregulates lipid metabolism and promotes glial activation in a mouse model of Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD). In particular, we aim to study the role of altered lipid metabolism and neuroinflammation in response to short (12 weeks) and prolonged (14-16 months) high-fat diet (H

…In particular, lipid metabolism dow

…studies reported that TBT could alter lipid metabolism, pointing out that more detailed studies are required to understand its multifaceted impact in aquatic animals.Adult (4-5-month) specimens of the great pond snail (Lymnaea stagnalis) were exposed to 100 ng/L TBT for 21 days. Potential histological, cellular, and molecular alterations were investigated in the CNS, kidney, and hepatopancreas.In the CNS,

…related to iron storage and metabolism. Investigating the role of microglia in aging can provide insights into disease identification and potential therapies. Despite being long-lived immune cells, microglia have been understudied in the context of aging. Their heterogeneity and functions have not been fully explored, which is important give

Little is known about the critical metabolic changes that neural cells have to undergo during development and how temporary shifts in this program can influence brain circuitries and behavior. Motivated by the identification of autism-associated mutations in SLC7A5, a transporter for metabolically essential large neutral amino acids (LNAAs), we utilized metabolomic profiling to investigate the metabolic states of the cerebral cortex across various developmental stages. Our findings reveal significant metabolic restructuring occurring in the forebrain throughout development, with specific group

Our goal is to understand why myelin repair fails in multiple sclerosis and to develop regenerative medicines for the nervous system. A central obstacle for progress in this area has been the complex biology underlying the response to CNS injury. Acute CNS damage is followed by a multicellular response that encompasses different cell types and spans different scales. Currently, we do not understand which factors determines lesion recovery. Failure of inflammation to resolve is a key underlying reason of poor regeneration, and one focus is therefore on the biology of microglia during de- and re

An imbalance in lipid metabolism in neurodegeneration is still poorly understood. Phospholipids (PLs) have multifactorial participation in vascular dementia as Alzheimer, post-stroke dementia, CADASIL between others. Which include the hyperactivation of phospholipases, mitochondrial stress, peroxisomal dysfunction and irregular fatty acid composition triggering proinflammation in a very early stage of cognitive impairment. The reestablishment of physiological conditions of cholesterol, sphingolipids, phospholipids and others are an interesting therapeutic target to reduce the progression of AD