Mutations

This conference examines the origins, distribution and consequences of mutations across cells, tissues, organisms and populations. Improved sequencing accuracy, experimental perturbations, multi-omic measurements and computational analysis are brought together to study genetic heterogeneity and its effects on genome function, evolution and disease. Sessions address mechanisms of mutagenesis, technologies for detecting and interpreting mutations, variation across the tree of life, tissue-level diversity, and evolutionary dynamics in cancer and other diseases. Researchers from genomics, mutagene

…The lecture asks how mutations accumulate during human life, how they contribute to cancer and how tumour evolution can be reconstructed. It illustrates how measurements of individual cells help address these questions.

…emergence of increasingly contagious mutations, repeatedly supplanting earlier strains. Following the near-absence of historical examples of the long-time evolution of infectious diseases under similar circumstances, models are crucial to exemplify possible scenarios. Accordingly, in the present work we systematically generalize the popular susceptible-infected-recovered model to account for mutations leading to repeatedly occurring new strains, which we coarse grain ba