Topic: precision medicine

The second M4H workshop brings mathematics, data science and medical research together to improve care. Mathematical models, numerical methods, statistics and machine learning support precision medicine, healthcare-resource allocation and multimodal patient-data analysis. Keynotes examine evolutionary cancer treatment and model-driven digital twins, longitudinal health records, topology and geometry for cyclic gene expression, statistical approaches to individual mental-health variation and patient-specific blood-flow simulation. Panels connect these methods with cardiovascular medicine, healt

The congress connects experimental and clinical pharmacology, from identifying therapeutic targets and testing mechanisms in preclinical models to clinical trials, access to treatment and evidence from routine care. Its programme examines synaptic and cellular communication in neurodegeneration, immunometabolism, inflammation, oncology, precision medicine and sex-aware experimental design. Sessions also address drug development, regulatory decisions, artificial intelligence and the sustainability of pharmacological research. Plenary lectures connect unmet needs in oncology to improved care and

Join Dr Eder Zavala’s Mathematical Biomedicine Group to analyse high-resolution hormone time series and wearable-device data for digital endocrinology and precision medicine. Research will characterise individual variation and misalignment of hormonal rhythms, integrate data analysis with models of responses to stressors, sleep disruption and disease, and develop personalised computational models. Methods include time-series and network analysis, Bayesian inference, machine learning, differential-equation modelling and high-performance simulation. The researcher will lead projects and collabor

Neuroimaging has greatly extended our capacity to study the workings of the human brain. Despite the wealth of knowledge this tool has generated however, there are still critical gaps in our understanding. While tremendous progress has been made in mapping areas of the brain that are specialized for particular stimuli, or cognitive processes, we still know very little about how large-scale interactions between different cortical networks facilitate the integration of information and the execution of complex tasks. Yet even the simplest behavioral tasks are complex, requiring integration over m

Monash Biomedical Imaging is part of the new $71.2 million Australian Precision Medicine Enterprise (APME) facility, which will deliver large-scale development and manufacturing of precision medicines and theranostic radiopharmaceuticals for industry and research. A key feature of the APME project is a high-energy cyclotron with multiple production clean rooms, which will be located on the Monash Biomedical Imaging (MBI) site in Clayton. This strategic co-location will facilitate radiochemistry, PET and SPECT research and clinical use of theranostic (therapeutic and diagnostic) radioisotopes p

Pathogenic variants in HCN1 are associated with severe developmental and epileptic encephalopathies (DEE). We have engineered the Hcn1 M294L heterozygous knock-in (Hcn1M294L) mouse which is a homolog of the de novo HCN1 M305L recurrent pathogenic variant. The mouse recapitulates the phenotypic features of patients including having spontaneous seizures and a learning deficit. In this talk I will present experimental work that probes the molecular and cellular mechanisms underlying hyper-excitability in the mouse model. This will include testing the efficacy of currently available antiepilepti