Circuit and synaptic mechanisms of plasticity in neural ensembles
Schedule
Friday, May 22, 2020
13:00 UTC
Ann-Marie Oswald
Prof
University of Pitsburgh
Host: The Neurotheory Forum
Recording
Open recording
Event Information
Recording
Available
Host
The Neurotheory Forum
Duration
70 minutes
Abstract
Inhibitory microcircuits play an important role regulating cortical responses to sensory stimuli. Interneurons that inhibit dendritic or somatic integration are gatekeepers for neural activity, synaptic plasticity and the formation of sensory representations. We have been investigating the synaptic plasticity mechanisms underlying the formation of ensembles in olfactory and orbitofrontal cortex. We have been focusing on the roles of three inhibitory neuron classes in gating excitatory synaptic plasticity in olfactory cortex- somatostatin (SST-INs), parvalbumin (PV-INs), and vasoactive intestinal polypeptide (VIP-INs) interneurons. Further, we are investigating the rules for inhibitory plasticity and a potential role in stabilizing ensembles in associative cortices. I will present new findings to support distinct roles for different interneuron classes in the gating and stabilization of ensemble representations of olfactory responses.
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