10 results
Develop a quantitative single-molecule imaging platform for drug discovery with Steven F. Lee. The initial focus is alpha-synuclein aggregation in Parkinson’s disease. Responsibilities include assay development, higher-throughput compound screening, image-analysis pipelines and coordination with academic and commercial partners. The role also contributes to…
Assistant Project Scientist in the structural biology of microtubule motors and regulatory proteins. The researcher will develop experiments and analyses involving molecular biology, biochemical reconstitution, cryo-electron microscopy sample preparation and imaging, single-particle structure determination using Relion and Cryosparc, and molecular model…
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A January–June 2027 placement with the Biotherapeutics Discovery team in Cambridge, Massachusetts. Work focuses on evaluating and improving therapeutic antibodies and VHH candidates through binding, biophysical and cell-based assays. Activities include protein production and purification, mammalian cell culture, ELISA, Octet measurements, size-exclusion…
RIKEN’s Life and Medical Science Application Interface Platform Development Unit, led by Yasuhiro Matsunaga, seeks postdoctoral researchers for the TRIP-AGIS project. Research integrates biomolecular simulation with AI: agents that plan and execute reproducible simulation workflows; molecular-dynamics surrogates with physical-validity and…
Develop deep-learning methods for generative protein design at the interface of machine learning, molecular simulation, structural biology and experimental protein engineering. Projects can investigate conformational ensembles, integrate protein language models with physics, or design proteins for challenging membrane and sugar interfaces. The researcher…
Develop high-throughput methods to measure how protein interactions respond to mechanical force. The project combines protein engineering, yeast surface display, directed evolution, deep sequencing and single-molecule force measurements, with machine-learning models trained on the resulting data. Initial applications study interactions involved in blood…
Develop theory and computational methods for complex biomolecular systems in Helmut Grubmüller’s group. Topics include variational free-energy methods, solvation-shell thermodynamics, constant-pH simulations and Markovian thermodynamics, with applications to ribosomes, fatty-acid synthase, CRISPR systems and intrinsically disordered proteins. Doctoral…
Help establish Leif-Thore Deck’s new research group and investigate biomolecular phase transitions across scales. The work combines droplet microfluidics and fluorescence microscopy with thermodynamic and kinetic measurements of protein and peptide condensates, fibrils and crystals, connecting microscopic nucleation processes to litre-scale precipitation.…
Develop computational algorithms and software that integrate high-performance computing with experimental imaging, scattering and time-resolved data to study biomolecular dynamics. The Computational Structural Biology Research Team collaborates with experimental groups on biologically relevant molecules. Appointments begin on or after 1 October 2026, with…
Melody is recruiting a protein engineer to create biosensors from allosteric switches, signaling motifs, reporter proteins, site-specific chemical modifications, and bioelectronic interfaces. The role spans construct design, wet-lab screening, device integration, experimental or computational protein design, and mentoring within a continuous…
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