Microbiome

…neuroscience, brain stimulation, the microbiome and brain health consider how stress, everyday behavior and social and environmental conditions can affect resilience over a lifetime. The panel discusses emerging evidence about early vulnerability, possible interventions through lifestyle changes and stress management, and more targeted approaches. It also addresses the limits of current knowledge and the uncertainties that remain when translating these findings into ways to protect

…only show reduced diversity in their microbiome compared to healthy controls, but also several parameters of elevated peripheral and central inflammation. The Poly I:C mouse model is based on epidemiological findings

…function and behaviour, andthe gut microbiome, are poor diet and psychological stress. While there isstrong evidence for interactions between the microbiome and host physiology inthe context of ch

…reveal substantial effects of the microbiome on neurophysiology, neuroimmunity and animal behavior. Despite these findings supporting a “microbiome-gut-brain axis”, the molecular and cellular mechanisms that underlie interactions between the gut microbiota and brain remain poorly understood. To uncover these, the Hsiao laboratory is mining the human microbiota for microbial modulators of host neuroactive molecules, investigating the impact of microbiota-immune system interacti

We are interested in understanding how microbes impact the behavior of host animals. Animal nervous systems likely evolved in environments richly surrounded by microbes, yet the impact of bacteria on nervous system function has been relatively under-studied. A challenge has been to identify systems in which both host and microbe are amenable to genetic manipulation, and which enable high-throughput behavioral screening in response to defined and naturalistic conditions. To accomplish these goals, we use an animal host — the roundworm C. elegans, which feeds on bacteria — in combination with it