15 results
Lead discovery of lipid nanoparticle systems that deliver RNA beyond the liver. The director coordinates lipid chemistry, formulation, protein design and bioconjugation with cell-based assays and animal studies. Responsibilities include translating delivery research across species, directing a research team and shaping scientific publications and…
Develop downstream purification processes for mRNA drug substance and transfer them to external GMP manufacturers. The engineer evaluates chromatography, filtration and concentration operations, develops impurity-clearance strategies and scales processes from laboratory to pilot production. Responsibilities include partner-site technical support and…
Support the scientific qualification and testing of raw materials used in therapeutic manufacturing at Beam’s Durham site. Responsibilities include material specifications, risk assessments, sampling, laboratory testing, interpretation of compendial methods and review of external testing. The analyst also investigates unexpected results and works with…
Lead the Massachusetts quality control laboratory supporting clinical and late-stage gene and cell therapy programmes. The work covers release and stability testing, analytical method qualification and transfer, laboratory investigations and interpretation of quality trends. The associate director develops laboratory staff and coordinates analytical…
A January–June 2027 technical operations placement supporting equipment and process validation for gene editing medicines. The student reviews scientific and engineering information, evaluates manufacturing data and prepares technical summaries for cross-functional teams supporting hematology and liver programmes. Based in Durham, North Carolina, the role…
A January–June 2027 process engineering placement developing targeted lipid nanoparticle formulations in Cambridge, Massachusetts. The work investigates mixing, filtration and tangential-flow filtration, and links process conditions to nanoparticle quality, stability and scalability. The student designs and executes experiments, analyses performance and…
A January–June 2027 placement supporting late-stage clinical cell therapy manufacturing in Durham, North Carolina. Projects examine aseptic process simulation, process validation and the robustness of manufacturing operations. The student helps develop protocols, analyse process data and prepare technical reports while working with manufacturing, quality…
Develop, optimise and transfer RNA manufacturing processes supporting Prime Editing programmes. Hands-on work includes solid-phase synthesis of long guide RNAs, chromatography, tangential-flow filtration and lyophilisation across scales, alongside GLP/GMP material production, analytical interpretation and technical documentation. The position works across…
Lead lipid-nanoparticle formulation, characterisation and process scale-up for investigational gene-editing therapies. Responsibilities span mixing and tangential-flow filtration from bench to GLP/GMP scale, process optimisation, external manufacturing transfer and contributions to regulatory CMC documentation. The position connects delivery technology with…
Lead global chemistry, manufacturing and controls regulatory strategy for small-molecule and monoclonal-antibody medicines. The role oversees investigational and marketing submissions, manufacturing-change assessments and health-authority interactions, working with process development, analytical development and quality teams from early development through…
Develop non-invasive neurotechnology based on focused ultrasound and targeted drug delivery. Projects may combine hardware and software, MRI-guided targeting, electrophysiology, closed-loop neuromodulation and preclinical experiments, with collaboration on clinical translation.
Engineer ultrasound-responsive drug carriers for targeted delivery to the brain. Work may include formulation and synthesis, loading and release measurements, microfluidic production, analytical characterisation and integration with ultrasound systems for translational studies.
Develop crystallization and precipitation processes for peptide biopharmaceuticals in Leif-Thore Deck’s group. The doctorate combines litre-scale experimental systems, particle characterization, image-based process monitoring and automation with modelling and microfluidic insights. Research includes downstream separation and redissolution to connect…
Develop generative and foundation models to design and assess linear and circular mRNA therapeutics. Work includes large-scale pretraining, model finetuning, hyperparameter optimisation and evaluation against experimental data. The project targets vaccine stability, unwanted immune responses and development speed for infectious-disease and cancer…
Develop medical materials that control biological responses, including healing, immune regulation, stem-cell differentiation or timed drug delivery. Several permanent research positions are available in the Research Center for Macromolecules and Biomaterials. The expected start is 1 April 2027, negotiable. Applications are reviewed as received and accepted…
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