Post-Doctoral Fellowship in Bioinformatics
Investigate immune regulation in sepsis, particularly neuroimmune and interorgan communication, using computational analyses of bulk and single-cell sequencing datasets. The project is funded by FAPESP and is expected to start in November 2026. The advertisement lists 31 October 2026 as its application deadline and states that review starts immediately and continues until the position is filled. Submit a CV, research-interest cover letter and contact details for two references to the investigator listed on the official page.
Cascadia Mucosal Biology Symposium
The inaugural Cascadia Mucosal Biology Symposium brings together mucosal biologists and immunologists to discuss mechanistic and translational research on health and disease at mucosal surfaces. Topics include tissue-immune crosstalk, microbial homeostasis, antigen-specific barrier responses, barrier development and repair, and translation to medicine.
Postdoctoral Scientist - Waldor Lab
Matt Waldor's laboratory at Brigham and Women's Hospital seeks a postdoctoral scientist to lead research on bacterial pathogens, virulence mechanisms, and host responses with potential translation to vaccines and therapeutics.
How Your Immune System Works & How to Improve It | Dr. Max Krummel
Andrew Huberman and immunologist Max Krummel discuss immune function, sleep, emotions, memory, the thymus, autoimmunity, cancer and immunization.
The immunopathogenesis of autoimmune seizure disorders
Immune-mediated mechanisms are increasingly recognised as a cause of epilepsy even in the absence of an immune response against a specifical neuronal antigen. In some cases, these autoimmune processes are clearly pathogenic, for example acute seizures in autoimmune encephalitis, whereas in others this is less clear, for example autoimmune-associated epilepsy. Recent research has provided novel insights into the clinical, paraclinical and immunopathogenetic mechanisms in these conditions. I will provide an overview of clinical and paraclinical features of immune-associated seizures. Furthermore, I will describe specific immunopathogenic examples implicating lymphoid follicular autoimmunisation and intrathecal B cells in these conditions. These insights into immunopathogenesis may help to explain the role of current and immunotherapies in these conditions.
Aging promotes reactivation from metastatic melanoma dormancy
How does the primary tumor imprint a dormancy signature in disseminated tumor cells?
T cells specific for alpha-myosin drive immunotherapy-related myocarditis
CD8+ T cell activation in cancer comprises an initial activation phase in lymph nodes followed by effector differentiation within the tumor
Immune regulation by fungal strain diversity in inflammatory bowel disease
Associations between brain interoceptive network dysconnectivity and heightened peripheral inflammation in depression
Are the immune system, brain, mind and mood related? Could this explain why chronic low-grade peripheral inflammation is also noted in approximately 1/3 of those with major depressive disorder (MDD)? The field recognized today as immunopsychiatry was founded on scientific evidence that germinated over 30 years ago. Since, it has been understood that (i) there could be a causal link between inflammation and depression, (ii) select blood immune markers show robust potential as biomarkers for inflammation-linked depression, and more generally, (iii) Descartes' theories on mind-body dualism were biologically erroneous. Nonetheless, the mechanistic brain-immune axis in the trinity formulating inflammation-linked depression i.e. psycho-neuro-immunology, still remains unclear. This talk will discuss findings from our recent investigation endeavored to unpack this by linking functional connectivity abnormalities with peripheral immune markers.
Coevolutionary processes in the adaptive immune system
Interactions of antibodies and bacteria in the digestive tract
Robotic mapping and generative modelling of cytokine response
We have developed a robotic platform allowing us to monitor cytokines dynamics (including IL-2, IFN-g, TNF, IL-6) of immune cells in vitro, with unprecedented resolution. To understand the complex emerging dynamics, we use interpretable machine learning techniques to build a generative model of cytokine response. We discover that, surprisingly, immune activity is encoded into one global parameter, encoding ligand antigenic properties and to a less extent ligand quantity. Based on this we build a simple interpretable model which can fully explain the broad variability of cytokines dynamics. We validate our approach using different lines of cells and different ligands. Two processes are identified, connected to timing and intensity of cytokine response, which we successfully modulate using drugs or by changing conditions such as initial T cell numbers. Our work reveals a simple "cytokine code", which can be used to better understand immune response in different contexts including immunotherapy. More generally, it reveals how robotic platforms and machine learning can be leveraged to build and validate systems biology models.
Can machine learning learn new physics, or do we need to put it in by hand?"\
There has been a surge of publications on using machine learning (ML) on experimental data from physical systems: social, biological, statistical, and quantum. However, can these methods discover fundamentally new physics? It can be that their biggest impact is in better data preprocessing, while inferring new physics is unrealistic without specifically adapting the learning machine to find what we are looking for — that is, without the “intuition” — and hence without having a good a priori guess about what we will find. Is machine learning a useful tool for physics discovery? Which minimal knowledge should we endow the machines with to make them useful in such tasks? How do we do this? Eight speakers below will anchor the workshop, exploring these questions in contexts of diverse systems (from quantum to biological), and from general theoretical advances to specific applications. Each speaker will deliver a 10 min talk with another 10 minutes set aside for moderated questions/discussion. We expect the talks to be broad, bold, and provocative, discussing where the field is heading, and what is needed to get us there.